Pseudomonas aeruginosa biofilms simulated in BioDynaMo

The first agent based model known to accurately capture the physical phenomena of biofilms growing under constant fluid flow, with experimental validation, is a BioDynaMo based model of Pseudomonas Aeruginosa biofilms.

From DOI: 10.1038/s41522-026-01052-1


As of 2019, biofilms (microbial communities that secrete an adhesive extracellular polymeric substance (EPS), allowing cells to attach to surfaces and resist harsh conditions) have been reported to have a global economic significance of almost $4trillion.

Read the manuscript, published under a Creative Commons Attribution 4.0 International (CC BY 4.0) licence, here

Location: Surrey, UK

Comments

Post a Comment

Popular posts from this blog

Modelling lung cells to personalize radiotherapy (with BioDynaMo) among the Top 10 Breakthroughs of the Year in physics for 2024!

Image
 Last December the 12th Physics World has delighted announced its Top 10 Breakthroughs of the Year for 2024, which includes research in nuclear and medical physics, quantum computing, lasers, antimatter and (of course ^_^) BioDynaMo . The Top Ten is the shortlist for the Physics World Breakthrough of the Year, which will be revealed on Thursday 19 December. PhysicsWorld editorial team has looked back at all the scientific discoveries reported on since 1 January and has picked 10 they judge are the most important. In addition to being reported in Physics World in 2024, the breakthroughs must meet the following criteria:  Significant advance in knowledge or understanding Importance of work for scientific progress and/or development of real-world applications Of general interest to Physics World readers  You can listen to the editors making their case for the research in the Top10 in this podcast What do they say about the BioDynaMo research they selected: <<Modelling...
Read more

Mechanistic model of radiotherapy-induced lung fibrosis using coupled BioDynaMo and Monte Carlo simulations

Image
 We are proud to announce the newly published manuscript " Mechanistic model of radiotherapy-induced lung fibrosis using coupled 3D agent-based and Monte Carlo simulations " by Nicolò Cogno , Roman Bauer , and Marco Durante , appearing on  Communications Medicine volume 4, Article number: 16 (2024). Fig. 1: Alveolar segment model in TOPAS-nBio . In this work, the authors develop and characterize a coupled 3D agent-based – Monte Carlo model that mechanistically simulates the onset of the radiation-induced lung fibrosis in an alveolar segment, laying thus the groundwork for further investigating the effects of different radiotherapeutic treatments on the onset of radiation-induced lung fibrosis via mechanistic modelling. The featured 3D agent based models are (of course) developed using the open-source platform BioDynaMo , and the implementation details have been shared in previous work by the same trio  here , and here . Without further ado, if you are interested in ...
Read more