According to the GLOBOCAN collaboration, cancer is one of the deadliest diseases worldwide and was responsible for one out of six fatalities in 2020 , and the estimated global economic cost of cancers from 2020 to 2050 is substantial, $25.2 trillion in international dollars (at constant 2017 prices), equivalent to an annual tax of 0.55% on global GDP . Graphical abstract of DOI: 10.1016/j.cma.2023.116566 It comes to no surprise that the rate of oncology indication approvals has increased, from January 2000 to October 2022, driven by approvals for targeted therapies, as has the rate of introduction of new therapeutic approaches . If drugs are becoming ever more precise, and the number of potential targets is growing, our ability to aim (to match the treatments and patients and disease evolution) is coming under stress and initiatives the US Cancer Moonshot programme , focusing on high-tech science, big data, and patient-centred care, bear witness to the huge ef...
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