Bridging Scales: a Hybrid Model to Simulate Vascular Tumor Growth and Treatment Response

Tobias Duswald, Ernesto A.B.F. Lima, J. Tinsley Oden, Barbara Wohlmuth have recently shared a very exciting pre-print going by the title "Bridging Scales: a Hybrid Model to Simulate Vascular Tumor Growth and Treatment Response"


In their work the authors set to contribute to our understanding of tumour growth dynamics and, ultimately, to offer a tool to more effectively explore candidate treatment strategies, by exploiting computer simulations. In facts, the manuscript introduces a computational model to simulate vascular tumor growth, and its response to drug treatments, in 3D. It is based on two agent-based models for the tumor cells and the vasculature coevolving.

The model focuses explicitly on breast cancer cells over-expressing HER2 receptors and a treatment combining standard chemotherapy (Doxorubicin) and monoclonal antibodies with anti-angiogenic properties (Trastuzumab). However,  large parts of the work presented can generalize to other scenarios.

Very exciting application of BioDynaMo, and we look forward to seeing it published in peer-reviewed literature, and maybe presented in a short video seminar, so stay tuned ;)

Location: Geneva, Switzerland

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